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 once;〃 the true reading being probably five…and…twenty DROPS; which are held equal to about one grain of crude opium。

{13}  Amongst the great herd of travellers; &c。; who show sufficiently by their stupidity that they never held any intercourse with opium; I must caution my readers specially against the brilliant author of Anastasius。  This gentleman; whose wit would lead one to presume him an opium…eater; has made it impossible to consider him in that character; from the grievous misrepresentation which he gives of its effects at pp。 215…17 of vol。 i。  Upon consideration it must appear such to the author himself; for; waiving the errors I have insisted on in the text; which (and others) are adopted in the fullest manner; he will himself admit that an old gentleman 〃with a snow…white beard;〃 who eats 〃ample doses of opium;〃 and is yet able to deliver what is meant and received as very weighty counsel on the bad effects of that practice; is but an indifferent evidence that opium either kills people prematurely or sends them into a madhouse。  But for my part; I see into this old gentleman and his motives:  the fact is; he was enamoured of 〃the little golden receptacle of the pernicious drug〃 which Anastasius carried about him; and no way of obtaining it so safe and so feasible occurred as that of frightening its owner out of his wits (which; by the bye; are none of the strongest)。  This commentary throws a new light upon the case; and greatly improves it as a story; for the old gentleman's speech; considered as a lecture on pharmacy; is highly absurd; but considered as a hoax on Anastasius; it reads excellently。

{14}  I have not the book at this moment to consult; but I think the passage begins〃And even that tavern music; which makes one man merry; another mad; in me strikes a deep fit of devotion;〃 &c。

{15}  A handsome newsroom; of which I was very politely made free in passing through Manchester by several gentlemen of that place; is called; I think; The Porch; whence I; who am a stranger in Manchester; inferred that the subscribers meant to profess themselves followers of Zeno。  But I have been since assured that this is a mistake。

{16}  I here reckon twenty…five drops of laudanum as equivalent to one grain of opium; which; I believe; is the common estimate。 However; as both may be considered variable quantities (the crude opium varying much in strength; and the tincture still more); I suppose that no infinitesimal accuracy can be had in such a calculation。  Teaspoons vary as much in size as opium in strength。 Small ones hold about 100 drops; so that 8;000 drops are about eighty times a teaspoonful。  The reader sees how much I kept within Dr。 Buchan's indulgent allowance。

{17}  This; however; is not a necessary conclusion; the varieties of effect produced by opium on different constitutions are infinite。  A London magistrate (Harriott's Struggles through Life; vol。 iii。 p。 391; third edition) has recorded that; on the first occasion of his trying laudanum for the gout he took FORTY drops; the next night SIXTY; and on the fifth night EIGHTY; without any effect whatever; and this at an advanced age。  I have an anecdote from a country surgeon; however; which sinks Mr。 Harriott's case into a trifle; and in my projected medical treatise on opium; which I will publish provided the College of Surgeons will pay me for enlightening their benighted understandings upon this subject; I will relate it; but it is far too good a story to be published gratis。

{18}  See the common accounts in any Eastern traveller or voyager of the frantic excesses committed by Malays who have taken opium; or are reduced to desperation by ill…luck at gambling。

{19}  The reader must remember what I here mean by THINKING; because else this would be a very presumptuous expression。  England; of late; has been rich to excess in fine thinkers; in the departments of creative and combining thought; but there is a sad dearth of masculine thinkers in any analytic path。  A Scotchman of eminent name has lately told us that he is obliged to quit even mathematics for want of encouragement。

{20}  William Lithgow。  His book (Travels; &;c。) is ill and pedantically written; but the account of his own sufferings on the rack at Malaga is overpoweringly affecting。

{21}  In saying this I mean no disrespect to the individual house; as the reader will understand when I tell him that; with the exception of one or two princely mansions; and some few inferior ones that have been coated with Roman cement; I am not acquainted with any house in this mountainous district which is wholly waterproof。  The architecture of books; I flatter myself; is conducted on just principles in this country; but for any other architecture; it is in a barbarous state; and what is worse; in a retrograde state。

{22}  On which last notice I would remark that mine was TOO rapid; and the suffering therefore needlessly aggravated; or rather; perhaps; it was not sufficiently continuous and equably graduated。 But that the reader may judge for himself; and above all that the Opium…eater; who is preparing to retire from business; may have every sort of information before him; I subjoin my diary:…

First Week                   Second Week        Drops of Laud。           Drops of Laud。 Mond。 June 24 。。。 130    Mond。 July  1 。。。  80            25 。。。 140                2 。。。  80            26 。。。 130                3 。。。  90            27 。。。  80                4 。。。 100            28 。。。  80                5 。。。  80            29 。。。  80                6 。。。  80            30 。。。  80                7 。。。  80 Third Week                   Fourth Week Mond。 July  8 。。。 300    Mond。 July 15 。。。  76             9 。。。  50               16 。。。  73。5            10 }                     17 。。。  73。5            11 } Hiatus in           18 。。。  70            12 } MS。                 19 。。。 240            13 }                     20 。。。  80            14 。。。  76               21 。。。 350 Fifth Week Mond。 July 22 。。。  60            23 。。。 none。            24 。。。 none。            25 。。。 none。            26 。。。 200            27 。。。 none。

What mean these abrupt relapses; the reader will ask perhaps; to such numbers as 300; 350; &c。?  The IMPULSE to these relapses was mere infirmity of purpose; the MOTIVE; where any motive blended with this impulse; was either the principle; of 〃reculer pour mieux sauter;〃 (for under the torpor of a large dose; which lasted for a day or two; a less quantity satisfied the stomach; which on awakening found itself partly accustomed to this new ration); or else it was this principlethat of sufferings otherwise equal; those will be borne best which meet with a mood of anger。  Now; whenever I ascended to my large dose I was furiously incensed on the following day; and could then have borne anything。







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