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Under¡¡this¡¡hypothesis£»¡¡that¡¡man¡¡in¡¡disease£»¡¡as¡¡in¡¡health£»¡¡is¡¡the¡¡product¡¡of¡¡his¡¡phylogeny¡¡as¡¡well¡¡as¡¡of¡¡ontogeny£»¡¡the¡¡sphere¡¡of¡¡the¡¡physician's¡¡activities¡¡takes¡¡on¡¡new¡¡aspects¡¡of¡¡far¡reaching¡¡and¡¡inspiring¡¡significance¡£¡¡¡¡Prognosis¡¡will¡¡become¡¡definite¡¡in¡¡proportion¡¡to¡¡the¡¡physician's¡¡knowledge¡¡not¡¡only¡¡of¡¡the¡¡ontogenetic¡¡history¡¡of¡¡the¡¡individual¡¡patient£»¡¡but¡¡also¡¡of¡¡the¡¡phylogenetic¡¡history¡¡of¡¡the¡¡race¡£¡¡As¡¡that¡¡knowledge¡¡increases£»¡¡as¡¡he¡¡appreciates¡¡more¡¡and¡¡more¡¡keenly¡¡the¡¡significance¡¡of¡¡environment¡¡in¡¡its¡¡effect¡¡upon¡¡individual¡¡development£»¡¡in¡¡so¡¡far¡¡will¡¡the¡¡physician¡¡be¡¡in¡¡a¡¡position¡¡to¡¡contribute¡¡mightily¡¡to¡¡the¡¡welfare¡¡of¡¡the¡¡race¡£
THE¡¡KINETIC¡¡SYSTEM£§*£§
£§*£§¡¡Address¡¡delivered¡¡before¡¡the¡¡New¡¡York¡¡State¡¡Medical¡¡Society£»¡¡April¡¡28£»¡¡1914£»¡¡to¡¡which¡¡has¡¡been¡¡added¡¡a¡¡further¡¡note¡¡regarding¡¡studies¡¡of¡¡hydrogen¡¡ion¡¡concentration¡¡in¡¡the¡¡blood¡£
In¡¡this¡¡paper¡¡I¡¡formulate¡¡a¡¡theory¡¡which¡¡I¡¡hope¡¡will¡¡harmonize¡¡a¡¡large¡¡number¡¡of¡¡clinical¡¡and¡¡experimental¡¡data£»¡¡supply¡¡an¡¡interpretation¡¡of¡¡certain¡¡diseases£»¡¡and¡¡show¡¡by¡¡what¡¡means¡¡many¡¡diverse¡¡causes¡¡produce¡¡the¡¡same¡¡end¡¡effects¡£
Even¡¡should¡¡the¡¡theory¡¡prove¡¡ultimately¡¡to¡¡be¡¡true£»¡¡it¡¡will¡¡in¡¡the¡¡mean¡¡time¡¡doubtless¡¡be¡¡subjected¡¡to¡¡many¡¡alterations¡£¡¡¡¡The¡¡specialized¡¡laboratory¡¡worker¡¡will£»¡¡at¡¡first£»¡¡fail¡¡to¡¡see¡¡the¡¡broader¡¡clinical¡¡view£»¡¡and¡¡the¡¡trained¡¡clinician¡¡may¡¡hesitate¡¡to¡¡accept¡¡the¡¡laboratory¡¡findings¡£¡¡Our¡¡viewpoint¡¡has¡¡been¡¡gained¡¡from¡¡a¡¡consideration¡¡of¡¡both¡¡lines¡¡of¡¡evidence¡¡on¡¡rather¡¡a¡¡large¡¡scale¡£
The¡¡responsibility¡¡for¡¡the¡¡kinetic¡¡theory¡¡is¡¡assumed¡¡by¡¡myself£»¡¡while¡¡the¡¡responsibility¡¡for¡¡the¡¡experimental¡¡data¡¡is¡¡shared¡¡fully¡¡by¡¡my¡¡associates£»¡¡Dr¡£¡¡J¡£¡¡B¡£¡¡Austin£»¡¡Dr¡£¡¡F¡£¡¡W¡£¡¡Hitchings£»¡¡Dr¡£¡¡H¡£¡¡G¡£¡¡Sloan£»¡¡and¡¡Dr¡£¡¡M¡£¡¡L¡£¡¡Menten¡££§t£§
£§t£§¡¡From¡¡H¡£¡¡K¡£¡¡Cushing¡¡Laboratory¡¡of¡¡Experimental¡¡Medicine£»¡¡Western¡¡Reserve¡¡University£»¡¡Cleveland¡£
Introduction
The¡¡self¡preservation¡¡of¡¡man¡¡and¡¡kindred¡¡animals¡¡is¡¡effected¡¡through¡¡mechanisms¡¡which¡¡transform¡¡latent¡¡energy¡¡into¡¡kinetic¡¡energy¡¡to¡¡accomplish¡¡adaptive¡¡ends¡£¡¡¡¡Man¡¡appropriates¡¡from¡¡environment¡¡the¡¡energy¡¡he¡¡requires¡¡in¡¡the¡¡form¡¡of¡¡crude¡¡food¡¡which¡¡is¡¡refined¡¡by¡¡the¡¡digestive¡¡system£»¡¡oxygen¡¡is¡¡taken¡¡to¡¡the¡¡blood¡¡and¡¡carbon¡¡dioxid¡¡is¡¡taken¡¡from¡¡the¡¡blood¡¡by¡¡the¡¡respiratory¡¡system£»¡¡to¡¡and¡¡from¡¡the¡¡myriads¡¡of¡¡working¡¡cells¡¡of¡¡the¡¡body£»¡¡food¡¡and¡¡oxygen¡¡and¡¡waste¡¡are¡¡carried¡¡by¡¡the¡¡circulatory¡¡system£»¡¡the¡¡body¡¡is¡¡cleared¡¡of¡¡waste¡¡by¡¡the¡¡urinary¡¡system£»¡¡procreation¡¡is¡¡accomplished¡¡through¡¡the¡¡genital¡¡system£»¡¡but¡¡none¡¡of¡¡these¡¡systems¡¡was¡¡evolved¡¡primarily¡¡for¡¡the¡¡purpose¡¡of¡¡transforming¡¡potential¡¡energy¡¡into¡¡kinetic¡¡energy¡¡for¡¡specific¡¡ends¡£¡¡¡¡Each¡¡system¡¡transforms¡¡such¡¡amounts¡¡of¡¡potential¡¡into¡¡kinetic¡¡energy¡¡as¡¡are¡¡required¡¡to¡¡perform¡¡its¡¡specific¡¡work£»¡¡but¡¡no¡¡one¡¡of¡¡them¡¡transforms¡¡latent¡¡into¡¡kinetic¡¡energy¡¡for¡¡the¡¡purposes¡¡of¡¡escaping£»¡¡fighting£»¡¡pursuing£»¡¡nor¡¡for¡¡combating¡¡infection¡£¡¡The¡¡stomach£»¡¡the¡¡kidneys£»¡¡the¡¡lungs£»¡¡the¡¡heart¡¡strike¡¡no¡¡physical¡¡blow¡their¡¡role¡¡is¡¡to¡¡do¡¡certain¡¡work¡¡to¡¡the¡¡end¡¡that¡¡the¡¡blow¡¡may¡¡be¡¡struck¡¡by¡¡another¡¡system¡¡evolved¡¡for¡¡that¡¡purpose¡£¡¡¡¡I¡¡propose¡¡to¡¡offer¡¡evidence¡¡that¡¡there¡¡is¡¡in¡¡the¡¡body¡¡a¡¡system¡¡evolved¡¡primarily¡¡for¡¡the¡¡transformation¡¡of¡¡latent¡¡energy¡¡into¡¡motion¡¡and¡¡into¡¡heat¡£¡¡This¡¡system¡¡I¡¡propose¡¡to¡¡designate¡¡¡¨The¡¡Kinetic¡¡System¡£¡¨
The¡¡kinetic¡¡system¡¡does¡¡not¡¡directly¡¡circulate¡¡the¡¡blood£»¡¡nor¡¡does¡¡it¡¡exchange¡¡oxygen¡¡and¡¡carbon¡¡dioxid£»¡¡nor¡¡does¡¡it¡¡perform¡¡the¡¡functions¡¡of¡¡digestion£»¡¡urinary¡¡elimination£»¡¡and¡¡procreation£»¡¡but¡¡though¡¡the¡¡kinetic¡¡system¡¡does¡¡not¡¡directly¡¡perform¡¡these¡¡functions£»¡¡it¡¡does¡¡play¡¡indirectly¡¡an¡¡important¡¡role¡¡in¡¡each£»¡¡just¡¡as¡¡the¡¡kinetic¡¡system¡¡itself¡¡is¡¡aided¡¡indirectly¡¡by¡¡the¡¡other¡¡systems¡£
The¡¡principal¡¡organs¡¡which¡¡comprise¡¡the¡¡kinetic¡¡system¡¡are¡¡the¡¡brain£»¡¡the¡¡thyroid£»¡¡the¡¡adrenals£»¡¡the¡¡liver£»¡¡and¡¡the¡¡muscles¡£¡¡The¡¡brain¡¡is¡¡the¡¡great¡¡central¡¡battery¡¡which¡¡drives¡¡the¡¡body£»¡¡the¡¡thyroid¡¡governs¡¡the¡¡conditions¡¡favoring¡¡tissue¡¡oxidation£»¡¡the¡¡adrenals¡¡govern¡¡immediate¡¡oxidation¡¡processes£»¡¡the¡¡liver¡¡fabricates¡¡and¡¡stores¡¡glycogen£»¡¡and¡¡the¡¡muscles¡¡are¡¡the¡¡great¡¡converters¡¡of¡¡latent¡¡energy¡¡into¡¡heat¡¡and¡¡motion¡£
Adrenalin¡¡alone£»¡¡thyroid¡¡extract¡¡alone£»¡¡brain¡¡activity¡¡alone£»¡¡and¡¡muscular¡¡activity¡¡alone¡¡are¡¡capable¡¡of¡¡causing¡¡the¡¡body¡¡temperature¡¡to¡¡rise¡¡above¡¡the¡¡normal¡£¡¡¡¡The¡¡functional¡¡activity¡¡of¡¡no¡¡other¡¡gland¡¡of¡¡the¡¡body¡¡alone£»¡¡and¡¡the¡¡secretion¡¡of¡¡no¡¡other¡¡gland¡¡alone£»¡¡can¡¡cause¡¡a¡¡comparable¡¡rise¡¡in¡¡body¡¡temperaturethat¡¡is£»¡¡neither¡¡increased¡¡functional¡¡activity¡¡nor¡¡any¡¡active¡¡principle¡¡derived¡¡from¡¡the¡¡kidney£»¡¡the¡¡liver£»¡¡the¡¡stomach£»¡¡the¡¡pancreas£»¡¡the¡¡hypophysis£»¡¡the¡¡parathyroids£»¡¡the¡¡spleen£»¡¡the¡¡intestines£»¡¡the¡¡thymus£»¡¡the¡¡lymphatic¡¡glands£»¡¡or¡¡the¡¡bones¡¡can£»¡¡_per¡¡se_£»¡¡cause¡¡a¡¡rise¡¡in¡¡the¡¡general¡¡body¡¡temperature¡¡comparable¡¡to¡¡the¡¡rise¡¡that¡¡may¡¡be¡¡caused¡¡by¡¡the¡¡activity¡¡of¡¡the¡¡brain¡¡or¡¡the¡¡muscles£»¡¡or¡¡by¡¡the¡¡injection¡¡of¡¡adrenalin¡¡or¡¡thyroid¡¡extract¡£¡¡¡¡Then£»¡¡too£»¡¡when¡¡the¡¡brain£»¡¡the¡¡thyroid£»¡¡the¡¡adrenals£»¡¡the¡¡liver£»¡¡or¡¡the¡¡muscles¡¡are¡¡eliminated£»¡¡the¡¡power¡¡of¡¡the¡¡body¡¡to¡¡convert¡¡latent¡¡into¡¡kinetic¡¡energy¡¡is¡¡impaired¡¡or¡¡lost¡£¡¡I¡¡shall¡¡offer¡¡evidence¡¡tending¡¡to¡¡show¡¡that¡¡an¡¡excess¡¡of¡¡either¡¡internal¡¡or¡¡external¡¡environmental¡¡stimuli¡¡may¡¡modify¡¡one¡¡or¡¡more¡¡organs¡¡of¡¡the¡¡kinetic¡¡system£»¡¡and¡¡that¡¡this¡¡modification¡¡may¡¡cause¡¡certain¡¡diseases¡£¡¡¡¡For¡¡example£»¡¡alteratio